Time course and cellular localization of SARS-CoV nucleoprotein and RNA in lungs from fatal cases of SARS.
Identifieur interne : 003C48 ( Main/Exploration ); précédent : 003C47; suivant : 003C49Time course and cellular localization of SARS-CoV nucleoprotein and RNA in lungs from fatal cases of SARS.
Auteurs : John M. Nicholls [République populaire de Chine] ; Jagdish Butany ; Leo L M. Poon ; Kwok H. Chan ; Swan Lip Beh ; Susan Poutanen ; J S Malik Peiris ; Maria WongSource :
- PLoS medicine [ 1549-1676 ] ; 2006.
Descripteurs français
- KwdFr :
- Alvéoles pulmonaires (virologie), Anticorps monoclonaux, Autopsie, Facteurs temps, Humains, Hybridation in situ, Immunohistochimie, Muqueuse respiratoire (virologie), Protéines nucléocapside (analyse), RT-PCR, Réplication virale, Syndrome respiratoire aigu sévère (mortalité), Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (physiologie).
- MESH :
- analyse : Protéines nucléocapside.
- mortalité : Syndrome respiratoire aigu sévère.
- physiologie : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- virologie : Alvéoles pulmonaires, Muqueuse respiratoire, Syndrome respiratoire aigu sévère.
- Anticorps monoclonaux, Autopsie, Facteurs temps, Humains, Hybridation in situ, Immunohistochimie, RT-PCR, Réplication virale.
English descriptors
- KwdEn :
- Antibodies, Monoclonal, Autopsy, Humans, Immunohistochemistry, In Situ Hybridization, Nucleocapsid Proteins (analysis), Pulmonary Alveoli (virology), Respiratory Mucosa (virology), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (physiology), Severe Acute Respiratory Syndrome (mortality), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (virology), Time Factors, Virus Replication.
- MESH :
- chemical , analysis : Nucleocapsid Proteins.
- chemical : Antibodies, Monoclonal.
- mortality : Severe Acute Respiratory Syndrome.
- physiology : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- virology : Pulmonary Alveoli, Respiratory Mucosa, Severe Acute Respiratory Syndrome.
- Autopsy, Humans, Immunohistochemistry, In Situ Hybridization, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Virus Replication.
Abstract
Cellular localization of severe acute respiratory syndrome coronavirus (SARS-CoV) in the lungs of patients with SARS is important in confirming the etiological association of the virus with disease as well as in understanding the pathogenesis of the disease. To our knowledge, there have been no comprehensive studies investigating viral infection at the cellular level in humans.
DOI: 10.1371/journal.pmed.0030027
PubMed: 16379499
Affiliations:
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Le document en format XML
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Chan</name></author><author><name sortKey="Beh, Swan Lip" sort="Beh, Swan Lip" uniqKey="Beh S" first="Swan Lip" last="Beh">Swan Lip Beh</name></author><author><name sortKey="Poutanen, Susan" sort="Poutanen, Susan" uniqKey="Poutanen S" first="Susan" last="Poutanen">Susan Poutanen</name></author><author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J S Malik" last="Peiris">J S Malik Peiris</name></author><author><name sortKey="Wong, Maria" sort="Wong, Maria" uniqKey="Wong M" first="Maria" last="Wong">Maria Wong</name></author></analytic><series><title level="j">PLoS medicine</title><idno type="eISSN">1549-1676</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Autopsy</term><term>Humans</term><term>Immunohistochemistry</term><term>In Situ Hybridization</term><term>Nucleocapsid Proteins (analysis)</term><term>Pulmonary Alveoli (virology)</term><term>Respiratory Mucosa (virology)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (mortality)</term><term>Severe Acute Respiratory Syndrome (physiopathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Time Factors</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alvéoles pulmonaires (virologie)</term><term>Anticorps monoclonaux</term><term>Autopsie</term><term>Facteurs temps</term><term>Humains</term><term>Hybridation in situ</term><term>Immunohistochimie</term><term>Muqueuse respiratoire (virologie)</term><term>Protéines nucléocapside (analyse)</term><term>RT-PCR</term><term>Réplication virale</term><term>Syndrome respiratoire aigu sévère (mortalité)</term><term>Syndrome respiratoire aigu sévère (physiopathologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Nucleocapsid Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéines nucléocapside</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Alvéoles pulmonaires</term><term>Muqueuse respiratoire</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pulmonary Alveoli</term><term>Respiratory Mucosa</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Autopsy</term><term>Humans</term><term>Immunohistochemistry</term><term>In Situ Hybridization</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Time Factors</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Autopsie</term><term>Facteurs temps</term><term>Humains</term><term>Hybridation in situ</term><term>Immunohistochimie</term><term>RT-PCR</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cellular localization of severe acute respiratory syndrome coronavirus (SARS-CoV) in the lungs of patients with SARS is important in confirming the etiological association of the virus with disease as well as in understanding the pathogenesis of the disease. To our knowledge, there have been no comprehensive studies investigating viral infection at the cellular level in humans.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Beh, Swan Lip" sort="Beh, Swan Lip" uniqKey="Beh S" first="Swan Lip" last="Beh">Swan Lip Beh</name><name sortKey="Butany, Jagdish" sort="Butany, Jagdish" uniqKey="Butany J" first="Jagdish" last="Butany">Jagdish Butany</name><name sortKey="Chan, Kwok H" sort="Chan, Kwok H" uniqKey="Chan K" first="Kwok H" last="Chan">Kwok H. Chan</name><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J S Malik" last="Peiris">J S Malik Peiris</name><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name><name sortKey="Poutanen, Susan" sort="Poutanen, Susan" uniqKey="Poutanen S" first="Susan" last="Poutanen">Susan Poutanen</name><name sortKey="Wong, Maria" sort="Wong, Maria" uniqKey="Wong M" first="Maria" last="Wong">Maria Wong</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M" last="Nicholls">John M. Nicholls</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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